Feverfew may also be used for purposes not listed in this product guide. CONDITIONS OF USE AND IMPORTANT INFORMATION: You should not use this product if you are allergic to feverfew or if you have: easy bruising or bleeding (nosebleeds, bleeding gums); allergies to chamomile, ragweed, yarrow, or other plants in the Asteraceae family; or. de Weerdt GJ, Bootsman HPR, Hendriks H. Herbal medicines in migraine prevention. Feverfew inhibits the effects of polymorphonuclear leukocyte granules that … Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. • Digestive upsets such as wind, bloating, nausea, constipation or diarrhoea. Other drugs may interact with feverfew, including prescription and over-the-counter medicines, vitamins, and herbal products. The active compound in feverfew is called parthenolide. Sumner H, Salan U, Knight DW, Hoult JR. Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. Barsby RW, Salan U, Knight DW, Hoult JR. Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta. Jain NK, Kulkarni SK. Neurology 1994;44(Suppl 2):A201. Does feverfew have any side effects? Although not all side effects are known, feverfew is thought to be likely safe when taken for a short period of time (up to 4 months). The Bottom Line. The active principle in feverfew. Pfaffenrath V, Diener HC, Fischer M, et al. J Herbs Spices Med Plants 1998;5(4):95-98. Waller, P. C. and Ramsay, L. E. Efficacy of feverfew as prophylactic treatment of migraine. Diener HC, Pfaffenrath V, Schnitker J, et al. Call your doctor for medical advice about side effects. The difference in results may be due to the many different feverfew products that were tested. Feverfew might decrease how quickly the liver breaks down some medications. The efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxis--a double-blind, multicentre, randomized placebo-controlled dose-response study. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. Taking feverfew along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Phytother Res 1997;11(7):508-511. An occlusive dressing containing betamethasone valerate 0.1% for the treatment of prurigo nodularis. The combined effect of acupuncture and Tanacetum parthenium on quality of life in women with headache: randomised study. Side effects of feverfew use may include abdominal pain, nausea, vomiting, indigestion, flatulence, diarrhea, and nervousness. Prostaglandins Leukot Med 1982;8:653-60. Feverfew in the treatment of migraine: its effect on serotonin uptake and platelet activity. View abstract. Ernst E, Pittler MH. Biochem Biophys Res Commun 1996;226:810-8.. View abstract. Prusinski A, Durko A, and Niczyporuk-Turek A. How Long Does Coronavirus Live On Surfaces? Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with FEVERFEW. View abstract. As feverfew is similar to aspirin and other NSAIDs such as ibruprofen, it is probably best not to take both at the same time. Neurol.Neurochir.Pol. View abstract. What are the side effects of feverfew (tanacetum parthenium)-oral? Adverse reactions in patients administered feverfew 50 mg/day (roughly equivalent to 2 leaves) during 6 months of treatment were mild and did not result in discontinuation, with 4 of 8 patients experiencing no adverse effects. Feverfew is likely safe when taken for a short period of time in appropriate doses. Kemper, K. J. and Breuner, C. C. Complementary, holistic, and integrative medicine: headaches. Taking feverfew along with some medications that are broken down by the liver can increase the effects and side effects of some medications. This information may not fit your specific health circumstances. Continuum (Minneap.Minn.) Lancet 1985;1:1071-4. Cochrane Database Syst Rev 2004;(1):CD002286. May Ease Arthritis Pain. Parthenocide: the demise of a facile theory of feverfew activity. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. View abstract. Feverfew has also been used to treat rheumatoid arthritis. If you need surgery, dental work, or a medical procedure, stop taking feverfew at least 2 weeks ahead of time. Lancet 1997;350:1598-9. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. However, studies have only looked into its short-term effects on the body. All rights reserved. Kuritzky A, Elhacham Y, Yerushalmi Z, and et al. View abstract. Feverfew extract is an essential supplement for humanity. Select one or more newsletters to continue. Do not take feverfew if: 1. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It contains a rebound of migraine disorders, insomnia, anxiety, myalgias, and arthralgias . Ital J Pediatr. View abstract. (check all that apply). Consult with a licensed healthcare professional before using any herbal/health supplement. More troublesome is a reported increase in heart rate in a few individuals. Some medications are changed and broken down by the liver. Austin, TX: Am Botanical Council, 1996. Cochrane Database Syst Rev. Uses, Benefits, Cures, Side Effects, Nutrients in Feverfew. 2012 Dec;30(4):252-7. Do not take topical (for the skin) feverfew by mouth. These side effects may include minor stomach upset (such as nausea, diarrhea, and flatulence), red itchy rash, and mouth ulcerations from chewing fresh feverfew leaves. View abstract. 2009;17:42-9. Melatonin in feverfew and other medicinal plants. J Herbs Spices Med Plants 1998;5:95-8. 2019;45(1):36. View abstract. Pittler MH, Vogler BK, Ernst E. Feverfew for preventing migraine. Curr Opin Neurol. Lancet 1980;2:922-3. Some research using feverfew alone or feverfew combined with other ingredients shows that taking feverfew by mouth can reduce the frequency and duration of migraine headaches and might reduce pain, nausea, vomiting, and sensitivity to light and noise when they do occur. View abstract. Is feverfew a pharmacologic agent? View abstract. View abstract. Effects such as abdominal pain, nausea, vomiting, diarrhea, indigestion, and gas, may also occur. View abstract. Biggs MJ, Johnson ES, Persaud NP, Ratcliffe DM. Headache 2004;44:885-90. However, other studies have failed to find the same results and suggested the benefits are due to the placebo effect. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Hwang D, Fischer NH, Jang BC, et al. Feverfew can affect blood-clotting and may increase your risk of bleeding. 2005;18(3):289-292. Feverfew is often sold as an herbal supplement. View abstract. View abstract. Pfaffenrath V, Fischer M, Friede M, and et al. View abstract. 2015 Apr 20;4:CD002286. Anti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium). Studies show that feverfew is safe, with mild and transient adverse effects (mainly mouth ulceration and gut-related symptoms) .However, it can cause withdrawal-like symptoms if you stop taking it abruptly [18, 56].Avoid it in the case of: 1. Foods and supplements in the management of migraine headaches. Common side effects may include: heartburn , upset stomach , nausea, vomiting; Chrysanthemumparthenium (L.) Bernh). Feverfew has mild interactions with at least 49 different drugs. People with allergies, especially to ragweed, may be sensitive to it. Collier HO, Butt NM, McDonald-Gibson WJ, Saeed SA. Efficacy of feverfew as prophylactic treatment of migraine. Pol.J.Pharmacol.Pharm. Randomized double-blind, placebo-controlled, crossover trial of a feverfew preparation. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Low concentrations of the feverfew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion. J Pharm Pharmacol 1988;40:743-5. Gromek, D., Kisiel, W., Stojakowska, A., and Kohlmunzer, S. Attempts of chemical standardizing of Chrysanthemum parthenium as a prospective antimigraine drug. Feverfew interactions with these medications might decrease how quickly the liver breaks these medications down or increase their side effects . Involvement of sesquiterpene lactones and other components. Do not take feverfew without medical advice if you are using a medication to treat any of the following conditions: any type of infection (including HIV, malaria, or tuberculosis); heartburn or gastroesophageal reflux disease (GERD); high blood pressure, high cholesterol, or a heart condition; psoriasis, rheumatoid arthritis, or other autoimmune disorders; This list is not complete. Not all possible interactions are listed in this product guide. feverfew CO2-extract (MIG-99) in migraine prevention--a randomized, double-blind, multicentre, placebo-controlled study. Guilbot A, Bangratz M, Ait Abdellah S, Lucas C. A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. Generic Name: feverfew (FEE ver few)Brand Name: Feverfew is an herb also known as Altamisa, Bachelor's Buttons, Chrysanthème Matricaire, Chrysanthemum Parthenium, Chrysanthemum praealtum, Featerfoiul, Featherfew, Featherfoil, Flirtwort Midsummer Daisy, Grande Camomille, Leucanthemum Parthenium, Matricaria, Pyrethrum Parthenium, Santa Maria, Tanaceti Parthenii, or Tanacetum Parthenium. Awang DVC. Phytomed 1996;3(3):225-230. Maizels M, Blumenfeld A, Burchette R. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. 1996;3(3):225-230. But there are also studies that show feverfew doesn't work for migraines. Phytochemistry 1995;38:267-70. Rapid Commun Mass Spectrom 2004;18:2273-81. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Using different formulations together increases the risk of an overdose. CMAJ 1999;160:21-2. 2006;26:287-96. 2011;5(9):103-110. View abstract. View abstract. Makheja AN, Bailey JM. [Epub ahead of print] View abstract. Heart rate increased dramatically (by up to 26 beats/min) in 2 patients. Some medications are changed and broken down by the liver. View abstract. Cochrane Database Syst Rev 2000;3:CD002286.
People who stop taking feverfew after using it for a long time may have withdrawal side effects. View abstract. Moscano F, Guiducci M, Maltoni L, et al. Palevitch D, Earon G, and Carasso R. Feverfew (Tanacetum parthenium) as a prophylactic treatment for migraine: a double-blind placebo-controlled study. Do not use more of this product than is recommended on the label. Pediatr.Rev. People who handle feverfew may develop a … As with aspirin feverfew should not be taken if you are breast feeding. Migraine. Public Health Nutr 2000;3:509-14. Extract of feverfew inhibits prostaglandin biosynthesis. The flavonoids of Tanacetum parthenium and T. vulgare and their anti-inflammatory properties. Folia Haematol Int Mag Klin Morphol Blutforsch 1988;115:447-9. Planta Med 1999;65:126-9. [Immunological and metabolic disorders and the means for their correction in patients with chronic bronchitis]. 1991;43(3):213-217. Common side effects of Tanacetum parthenium are oral ulcers and tongue soreness if dried leaves are chewed. Feverfew should not be used in place of medication prescribed for you by your doctor. Murphy JJ, Heptinstall S, Mitchell JR. Randomized, double-blind, placebo-controlled trial of feverfew in migraine prevention. Clinical dose-response study for the investigation of efficacy and tolerability of Tanacetum parthenium in migraine prophylaxis. Br.J.Pharmacol. Phytotherapy Res 1997;11:508-11. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. We comply with the HONcode standard for trustworthy health information -. Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. It is responsible for feverfew’s anti-inflammatory effects, and it may also have a potent anti-cancer mechanism. Randomized double-blind placebo-controlled crossover trial of a feverfew preparation. Lancet 1988;2:189-92. 2012;18(4):796-806. Unger M, Frank A. View abstract. Vogler BK, Pittler MH, Ernst E. Feverfew as a preventive treatment for migraine: a systematic review. Gelstat Migraine (sublingually administered feverfew and ginger compound) for acute treatment of migraine when administered during the mild pain phase. It is not certain whether feverfew is effective in treating any medical condition. This information does not contain all possible interactions or adverse effects. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). J Pharm Pharmacol 1987;39(6):466-470. Biochem Pharmacol 1992;43:2313-20. Do not use this product without medical advice if you are breast-feeding a baby. Foster S. Feverfew, Tanacetum parthenium, botanical series #310. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. View abstract. Lancet 1981;2:1054. DOI: 10.15436/2377-1348.17.1630. 2017;17(1):433. doi: 10.1186/s12906-017-1933-7. Williams CA, Harborne JB, Geiger H, Hoult JR. Feverfew is LIKELY SAFE when taken by mouth appropriately in the short-term (up to four months). Call your doctor if the condition you are treating with feverfew does not improve, or if it gets worse while using this product. Other side effects from feverfew affect the digestive system. When you are adding new supplements or herbal teas into your diet it is always important to familiarize yourself with any potential side effects that they may have. Feverfew has been used in alternative medicine as a possibly effective aid in preventing migraine headaches or reducing the symptoms of headaches that do occur. View abstract. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Hayes, N. A. and Foreman, J. C. The activity of compounds extracted from feverfew on histamine release from rat mast cells. It relieves menstrual cramps. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. See what others have said about Feverfew, including the effectiveness, ease of use and side effects. View abstract. View abstract. Awang DV. Wong HC. Feverfew drug interactions (in more detail). Feverfew side effects. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. View abstract. Itching. Cady RK, Schreiber CP, Beach ME, et al. Awang DV. Feverfew is LIKELY SAFE when taken by mouth appropriately in the short-term (up to four months). Information from this source is evidence-based and objective, and without commercial influence. Cephalalgia 1998;18:704-8. View abstract. Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases. Deutscher Schmerzkongress; October 20-24, 1999, Munich, Germany. View abstract. However, research has shown that feverfew may not be effective in treating this condition. Sign Up to Receive Our Free Coroanvirus Newsletter, How Different Types of pain Mediciations Works. Some medications that are changed by the liver include omeprazole (Prilosec), lansoprazole (Prevacid), and pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); and others. Before taking feverfew, talk to your healthcare provider if you are taking any medications that are changed by the liver. The researchers also found there were no serious side effects as a result of taking feverfew during the study.