A nurse-led integrated care management program (iCMP) aims to coordinate medical care and to uncover and address social determinants of health-related needs for medically and psychosocially complex patients at high risk for frequent emergency department visits and hospitalizations. Ashvattha Therapeutics, a clinical-stage biotech company focused on … All Days; Wed, Nov 4; Thu, Nov 5; Fri, Nov 6; Sat, Nov 7; Sun, Nov 8; Mon, Nov 9; Tue, Nov 10; Sat, Nov 21; Full Schedule - ACR Convergence 2020. Data that will contribute to our decision-making may include considering the severity of musculoskeletal disease, the severity of skin disease, and the safety of the treatment. Type here to filter the list. Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; ACR Convergence 2020 . Presented at: ACR Convergence 2020; November 5-9, 2020. Highlights of Abstracts From ACR Convergence 2020. Program and Faculty are updated daily - check back often for the most up-to-date information. Click to share on LinkedIn (Opens in new window), Click to share on Twitter (Opens in new window), Click to share on Facebook (Opens in new window), Click to email this to a friend (Opens in new window), Virtual Visits Accelerate Urology Patient Care, Optimizing Care for Every Patient With Genitourinary Cancer. “If we heed these lessons and implement change thoughtfully, rheumatology will enter a new era as an even more essential and highly sought-after specialty,” she said in her speech. Therapies to induce immune responses against tumors, such as anti-PD-1 antibodies, have revolutionized the treatment of many cancers. There were many studies that addressed “pre-PsA,” similar to pre-RA in patients with some arthralgias and a positive cyclic citrullinated peptide (CCP) test. They also evaluated individual components of BASDAI.4 These findings are quite interesting and make us think that perhaps axial PsA is different than axial SpA. - And More, Close more info about Expert Insights on Psoriatic Arthritis From ACR Convergence 2020. There is a hierarchy to follow depending on the severity of the patient’s PsA. One of the new agents for PsA is upadacitinib. The investigators also looked at enthesitis resolution, minimal disease activity, and Health Assessment Questionnaire Disability Index. For PsA, we do not have any antibodies such as rheumatoid factor or anti-CCP. Program and Faculty are updated daily - check back often for the most up-to-date information. ACR CONVERGENCE 2020—Moderated by Bill St.Clair, MD, MACR, an ACR past president and a professor of medicine and immunology at Duke University Medical Center, Durham, N.C., an abstract session on Friday, Nov. 6, focused on the diagnosis, manifestations and outcomes of rheumatoid arthritis (RA), with a focus on interstitial lung disease. If you wish to read unlimited content, please log in or register below. … JAK inhibitors have been approved for the treatment of rheumatoid arthritis (RA), and we know that they are fairly good with respect to the peripheral joints because of our experience with them in RA. If the disease is mild, you can use methotrexate. GRAPPA is working on their treatment guidelines, which are expected to be released at the end of 2021. Full Schedule - ACR Convergence 2020; Full Schedule - ACR Convergence 2020. Don’t miss out on today’s top content on Rheumatology Advisor. Dr. Liao’s team developed an algorithm using machine learning and NLP that reduced the number of charts requiring review by 40–45 percent compared to reviewing any subjects with an ICD code for rheumatoid arthritis (RA). Program and Faculty are updated daily - check back often for the most up-to-date information. All times listed are Eastern Standard Time. All Days; Fri, Nov 6 ; Full Schedule - 2020 ACR Convergence. At week 52, all patients remaining on ADL-EU were switched to ADL-PF. The SELECT – PsA 1 study also included adalimumab as a comparator. Zheni Stavre, MD; JungMin Kim, PhD; Jae-Hyuck Shim, PhD; Ellen M. Gravallese, MD. … Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Abstract Number: 1460 “Can I … Abstract 907. ET. November 5-9, 2020… Neither of these agents was found to be effective in patients with axial spondyloarthritis (SpA). Abstract Supplement ACR Convergence 2020 - 2020 - Arthritis & Rheumatology - Wiley … Thanks for visiting Rheumatology Advisor. here. This team targeted schnurri3 (Shn3) — a large, intracellular protein upregulated by TNF and IL-17A and known to be a suppressor of osteoblast activity — in specific bone cells in several mouse models of RA and determined its therapeutic potential in RA-induced bone loss. I’ll be covering these topics, and discussing select individual posters and abstracts during this meeting. The American College of Rheumatology’s annual Convergence conference, which took place Nov. 5–9, featured significant contributions from Brigham and Women’s Hospital physicians and scientists. Approximately 80% of patients with AS have the HLA-B27 gene, and only approximately 50% of patients with axial PsA have the HLA-B27. In this study, the team performed single-cell transcriptomic analysis (scRNAseq) of synovial vasculature to characterize vascular remodeling at a single-cell level. However, there was a significant ACR50/70 response in patients who received methotrexate alone. Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Abstract Number: 0403. … Dr. Rao led a team that used mass cytometry immunophenotyping to study the immune cells that accumulate in joint fluid of patients who develop inflammatory arthritis following anti-PD-1 therapy. Mease P, Lertratanakul A, Strober B, et al. The tally included over 120 abstracts: two plenary presentations, 36 oral presentations, one late-breaking poster and 86 poster … Mease P, Deodhar A, van der Heijde D, et al. Abstract 2026. What was reported at the ACR 2020 meeting was the effect of guselkumab on axial disease in PsA. Efficacy of guselkumab, a monoclonal antibody that specifically binds to the p19 subunit of il-23, on axial-related endpoints in patients with active psa with imaging-confirmed sacroiliitis: week-52 results from two phase 3, randomized, double-blind, placebo-controlled studies. If these patients have syndesmophytes, they are thin and run from the lower end of a vertebra to the upper end of the lower vertebra. Gravallese and Solomon lamented the inability to interact directly with fellow participants but noted an upside: About 16,400 people from 111 countries attended at least some portion of the conference, compared with the typical 9,000 to 10,000 attendees. I might then consider the IL-12/23 inhibitor ustekinumab because that drug has been in the market for quite some time and it is a very good drug with respect to the skin, although in my experience it is not as good a drug as TNF inhibitors for the joints. The tally included over 120 abstracts: two plenary presentations, 36 oral presentations, one late-breaking poster and 86 poster presentations. The only place for free North American stock rankings incorporating insider commitment. As I mentioned earlier, there are head-to-head studies showing that IL-17 inhibitors are as effective as TNF inhibitors; they are noninferior and superior in the skin. The study assessed whether the combination of methotrexate and etanercept was superior to etanercept alone. The surprise was that compared to adalimumab, which is a very good drug even for the skin, the response rate (Psoriasis Area and Severity Index [PASI] 90, PASI 100) with upadacitinib was found to be better than with adalimumab.1, The other abstract addressed upadacitinib in patients with inadequate response to TNF inhibitors; this study showed that patients with PsA demonstrated a good response to upadacitinib.2, Long-term data (week 52 and 100) from a study on another JAK1 inhibitor, filgotinib, showed that this drug works and maintains its efficacy in the long term. However, there are several clinical, genetic, and radiographic differences between axial PsA and axial SpA, and this is an active area of research. Abstract 1356. Minimal disease activity with filgotinib was found to be about 31% at week 100.3. Register for free and gain unlimited access to: - Clinical News, with personalized daily picks for you Here is a flavour of my read through … The study concluded that there is a high burden of these needs among medically and psychosocially complex patients with lupus and that iCMP can successfully uncover and begin to address these barriers to care. Information from the ACR presentations are under embargo until November 5, 2020 at 2:00 p.m. There were several interesting abstracts presented at this year’s ACR annual meeting from a therapy standpoint, some of which were also presented at the 2020 European League Against Rheumatism (EULAR) annual meeting. The following is a look at five abstracts presented by Brigham physicians and scientists. So, symmetric vs asymmetric sacroiliitis and thin vs chunky syndesmophytes would be 1 way of differentiating between axial PsA and axial SpA. So, this is another new and interesting class of drugs that we can look forward to. Mease P, Helliwell P, Gladwell D, et al. However, radiographic examination of these patients will demonstrate symmetric sacroiliitis. Abstract 2025. Accepted Late-Breaking abstracts will be available late October. The MAXIMISE study (ClinicalTrials.gov Identifier: NCT02721966) found secukinumab to be effective in patients with axial PsA, so it may not really matter to differentiate between the 2 conditions in day-to-day practice. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites . Abstract 907. One would also take into account whether there is significant skin involvement, as we know that IL-17 and IL-23 inhibitors are superior to TNF inhibitors with respect to the skin. Please login or register first to view this content. Haberman R, Perez-Chada L, Chandran V, et al. Type here to filter the list. There are also several types of drugs and there are many different classes of each drug: conventional synthetic disease-modifying antirheumatic drugs (DMARDs); TNF inhibitors (there are 5 of them); the IL-12/23 inhibitor (ustekinumab); IL-17 inhibitors (secukinumab and ixekizumab); pure IL-23 inhibitors (there are 3 of them; 1 has been approved for PsA [guselkumab], but rizankizumab and tildrakizumab are being studied in phase 2 trials presented at the ACR 2020 meeting); JAK inhibitors; the phosphodiesterase-4 (PDE4) inhibitor apremilast; and abatacept (a T-cell inhibitor that is mainly used for RA but has been approved for the treatment of PsA). Already have an account? November 5-9, 2020… Presented at: ACR Convergence 2020; November 5-9, 2020. All times listed are Eastern Standard Time. Importantly, exceedingly few potentially eligible patients were eliminated by screening using this algorithm. Once the posters are made public, they will be available on the Company’s website in the SELECT – PsA 1 was a study conducted among biologic-naive patients with PsA, and SELECT – PsA 2 was conducted among patients with PsA who had an inadequate response to treatment with a tumor necrosis factor (TNF) inhibitor. The ACR and NPF guidelines are very practical, and they answer exactly this question. Currently, there is no good way of defining axial PsA, although the Assessment of SpA International Society (ASAS) and the Group for Research and Assessment of Psoriasis and PsA (GRAPPA) are conducting a larger international study, the Axial Involvement in PsA Cohort (AXIS) study (ClinicalTrials.gov Identifier: NCT04434885), to define axial PsA and how to quantify these patients. The real clinical question is how to differentiate between a patient who has ankylosing spondylitis (AS) with skin psoriasis and a patient who has PsA and axial symptoms. We are now also observing that guselkumab, at least according to the results of DISCOVER-1 (ClinicalTrials.gov Identifier: NCT03162796) and DISCOVER-2 (ClinicalTrials.gov Identifier: NCT03158285) trials, has been found to have a strikingly good safety profile. Kevin S. Wei, MD, PhD; Ilya Korsunsky, PhD; Jennifer L. Marshall, PhD; Gerald F.M. The American College of Rheumatology’s annual Convergence conference, which took place Nov. 5–9, featured significant contributions from Brigham and Women’s Hospital physicians and scientists. - Full-Length Features Full Schedule - 2020 ACR Convergence. Norwood, MA, Oct. 21, 2020 (GLOBE NEWSWIRE) -- Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) (“Corbus” or the “Company”), a clinical-stage drug development company pioneering transformative medicines that target the endocannabinoid system, today announced the presentation of three abstracts at the American College of Rheumatology (“ACR”) Convergence 2020 being held … Dr. Gravallese summarized lessons learned during the pandemic, including the importance of rheumatologists as experts in immunology, the optimal use of telemedicine and virtual education and the importance of organizational change to allow societies and institutions to respond more nimbly to crises. Type here to filter the list. Friday, November 6, 2020; Poster Hall Hours | 9:00 - 11:00 AM Eastern Time; 9:00 AM – 11:00 AM ET. - Conference Coverage Watts, MSc; Trinn Major, PhD; Zhu, MSc; Yuhong Li, MSc; Christopher Buckley, MBBS; Soumya Raychaudhuri, MD, PhD; Michael B. Brenner, MD. Enjoying our content? Kiniksa Announces American College of Rheumatology Convergence 2020 Late-Breaking Abstracts Presentation of Mavrilimumab Phase 2 Giant Cell … McInnes I, Anderson JK, Magrey M, et al. - Case Studies “We hope that by understanding the similarities and differences between immune cells in different types of inflammatory arthritis, including checkpoint inhibitor-associated arthritis, we can identify specific signals that block the key pathologic signals in each condition,” Dr. Rao said. A phase 2 randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of the novel tyrosine kinase type 2 (Tyk2) inhibitor deucravacitinib and was presented in a late-breaking abstract at ACR 2020.6 Tyk2 is part of the Janus kinases. It is thought that IL-23 inhibitors have no effect on the axial skeleton based on 2 studies: the first one included risankizumab, another IL-23 p19 inhibitor, and the second one was on ustekinumab, an IL-12/23 inhibitor. Long-term outcomes with filgotinib, an oral selective Janus kinase 1 inhibitor: 100-week data from an open-label extension (OLE) study in patients with active psoriatic arthritis (PsA). ACR CONVERGENCE 2020—The field of rheumatology is vast, with innumerable diseases to consider in each differential and with myriad possible presentations of each condition. There is a lot of work being conducted on standardizing the terminology for pre-PsA. They also aimed to understand whether social determinants of health-related needs such as food insecurity, housing instability and financial constraints were prevalent among patients with lupus enrolled in iCMP. Investigators said efficacy response rates at week 78 were 84.2% for all patients, and 83.4%, 85.8%, and 84.3% for the biosimilar, week 26 switch, and week 52 switch groups, respectively. Abstract 907. Get stock quotes, news, fundamentals and easy to read SEC and SEDI insider filings. The researchers indicated that methotrexate seems to have good efficacy in PsA, although the study had limitations because there was no placebo and it could be claimed that the methotrexate response was because of the placebo. Disclosure: Dr Atul A. Deodhar declared affiliations with the pharmaceutical industry. Efficacy and safety of upadacitinib versus placebo and adalimumab in patients with active psoriatic arthritis and inadequate response to non-biologic disease-modifying anti-rheumatic drugs: a double-blind, randomized controlled phase 3 trial. Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Welcome to the ACR/ARP Abstracts … We would like to show you a description here but the site won’t allow us. - Drug Monographs ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites. Abstract For a searchable version of these abstracts, please visit www.acrabstracts.org. In axial PsA, patients typically have asymmetric sacroiliitis and “chunky,” asymmetric, osteophyte-looking changes in the spine that run from the middle of the vertebra to the next vertebra. Full Schedule - ACR Convergence 2020; Full Schedule - ACR Convergence 2020. “The Brigham’s Division of Rheumatology, Inflammation, and Immunity provided an important scientific presence at the meeting, and many division members served as moderators and session leaders, contributing significantly to the meeting’s impact and success.”. Convergence 2020 highlighted several important treatment abstracts related to systemic lupus erythematosus. There was another presentation at ACR 2020 on whether there are risk factors in patients with skin psoriasis who develop PsA. Mease P, Helliwell P, Gladwell D, et al. Presented at: ACR Convergence 2020; November 5-9, 2020. Pages: 1-4231; First Published: 09 November 2020; Abstract; PDF; Request permissions; Tools. Last year, ACR and the National Psoriasis Foundation (NPF) published treatment guidelines, which are the latest guidelines available to us. Efficacy and safety of deucravacitinib (BMS-986165), an oral, selective tyrosine kinase 2 inhibitor, in patients with active psoriatic arthritis: results from a phase 2, randomized, double-blind, placebo-controlled trial. These investigators recently reported that a key step in pannus formation and fibroblast expansion in RA is driven by endothelial-derived Notch signaling. Program and Faculty are updated daily - check back often for the most up-to-date information. Accepted general abstracts from ACR Convergence 2020 can be searched and viewed online starting late September. In this case, as well, it wasn’t any different that upadacitinib worked well on the musculoskeletal component of PsA. Abstract LO3. The ACR abstracts are available online at the conference website.Information from the ACR presentations are under embargo until November 5, 2020 at 2:00 p.m. Presented at: ACR Convergence 2020; November 5-9, 2020. Home of the insider insights newsletter and the Canadian Insider Club which offers alerts and premium research. There are many differences in the presentation of these patients. According to the ACR-NPF treatment guidelines, which are a significant departure from older treatment guidelines and EULAR recommendations, patients with severe disease can directly receive a TNF inhibitor. However, one has to take this with a “pinch of salt” when one is looking at clinical trials that assess safety, as longer-term follow-up in postmarketing experience is needed. Shared decision-making is very important. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites . Sign in Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; ACR Convergence 2020 . Registration is free. The study highlights the power of single-cell transcriptomics in identifying cellular and molecular changes in organ tissues affected by inflammatory diseases. Copyright © 2020 Haymarket Media, Inc. All Rights Reserved Investigators examined whether iCMP was effective at decreasing the incidence rates of ED visits, hospitalizations and outpatient appointment no-shows. These studies showed that ixekizumab and secukinumab were superior to adalimumab with regard to the skin, and both drugs were both noninferior to adalimumab with regard to the joints. ACR CONVERGENCE 2020— Earlier this year, the ACR released an updated guideline for the management of gout, and approximately 50 abstracts of studies on various aspects of gout were accepted for presentation at ACR Convergence 2020. This site features news for physicians about research, innovation and clinical care at Brigham and Women’s Hospital. Important Dates . At 1 year, predictors of development of PsA included arthralgia, joint aches and pains, and fatigue. Guselkumab, an interleukin (IL)-23 p19 inhibitor, has been effective in PsA, as demonstrated by the results of phase 2 and phase 3 studies published in the Lancet. A presentation at ACR 2020 looked at the terminology in detail.5 In addition, there is an organization, PPACMAN (the Psoriasis & Psoriatic Arthritis Clinics Multicenter Advancement Network), in the United States that includes clinics in dermatology and rheumatology that is exploring pre-PsA terminology because unless these patients are defined carefully, it becomes challenging to study their condition. They assessed changes in BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), and, when guselkumab was compared to placebo, there was a statistically significant difference. In the United States, unfortunately, treatment also depends on what the insurance company will approve and patients’ out-of-pocket expenses. Presented at: ACR Convergence 2020; November 5-9, 2020. Results of the SEAM study (Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis; ClinicalTrials.gov Identifier: NCT02376790) were published last year and presented at the 2019 ACR annual meeting. With Phase 2 of the Accelerating Medicines Partnership (AMP) study of systemic lupus erythematosus (SLE) underway, an ACR Convergence 2020 session featured a panel that reviewed the methods being used to generate data and discussed some of the findings and insight gained from ongoing analyses of kidney and urine. Ashvattha Therapeutics Selected to Present Virtual Poster at ACR Convergence 2020. A Delphi consensus study to standardize terminology for the pre-clinical phase of psoriatic arthritis. All times listed are Eastern Standard Time. It is very important to assess the patients’ status in terms of how comfortable they are with the route of administration (oral vs injection), their risk tolerance, their insurance, etc. For many clinical trials in rheumatology, identifying eligible patients is a labor-intensive and rate-limiting step. These analyses identified enrichment of Notch receptor activation among arterial endothelial cells and a subset of capillaries, implicating Notch signaling during vascular remodeling in RA. If treatment with the TNF inhibitor fails, the class could be changed if it were a primary failure, and it can remain in the same class if it were a secondary failure. Abstract Supplement ACR Convergence 2020. At the ACR Convergence 2020, updated findings were presented for weeks 52 to 92 in patients who continued ADL-PF (N = 552). We were surprised to find the efficacy of Janus kinase (JAK) inhibitors on the skin. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting ; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites. Efficacy of upadacitinib in patients with psoriatic arthritis stratified by number of prior biologic disease-modifying anti-rheumatic drugs. For the first time, ACR Convergence 2020 was a virtual event. Fewer Options. You’ve viewed {{metering-count}} of {{metering-total}} articles this month. There are some really interesting poster and abstract presentations on spondyloarthritis at the ACR Convergence 2020. If it is more severe and there is involvement of numerous joints with polyarticular inflammation and skin involvement, you directly use a TNF inhibitor and avoid methotrexate. 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